Lyme disease is a complex and often misunderstood illness caused by the Borrelia burgdorferi bacteria, which is transmitted to humans through the bite of an infected tick. Lyme disease is specifically spread by infected ticks, which serve as the primary vectors for this condition. The initial condition caused by the bacteria is referred to as Lyme disease infection. While early Lyme disease is commonly treated with oral antibiotics, many patients continue to experience pain, fatigue, and joint inflammation long after completing treatment.
At PointHealth Clinic, we understand the challenges Lyme disease patients face—especially those dealing with chronic symptoms. The clinical manifestations of Lyme disease, such as joint pain, fatigue, and inflammation, can significantly impact daily life. Our approach focuses on whole-body healing, combining evidence-based treatment protocols with regenerative therapies to provide lasting pain relief and restore quality of life. If you suspect Lyme disease infection or have persistent symptoms, consult a healthcare provider for proper diagnosis and care.
Understanding Lyme Disease Pain
Lyme disease pain can affect:
- Muscles
- Joints (commonly the knees and large joints)
- Nerves and the central nervous system
- Cognitive function (brain fog, fatigue)
Neurological complications of Lyme disease can sometimes mimic other conditions, such as Alzheimer’s disease and Bell’s palsy, due to central nervous system involvement.
Pain may occur in both early stages (during active infection) and in post-treatment Lyme disease syndrome (PTLDS), when the infection is no longer active but inflammation and immune dysregulation persist.
Common sources of pain include:
- Lyme arthritis or chronic joint swelling
- Neuropathic pain (burning or tingling sensations)
- Persistent fatigue and muscle tenderness
- Headaches or migratory pain patterns
Some patients may experience long term symptoms, including persistent pain and neurological issues, even after initial treatment.
Understanding Lyme Arthritis
Lyme arthritis is one of the most common complications seen in the later stages of Lyme disease, often developing several months after the initial tick bite. This condition is marked by episodes of joint swelling and pain, most frequently affecting one or a few large joints, such as the knees. The swelling can be significant, sometimes accompanied by warmth and reduced mobility, leading to considerable musculoskeletal pain and discomfort.
Lyme arthritis may follow early stages of Lyme disease, which can include the characteristic erythema migrans skin lesion, even if the initial infection went unnoticed or was asymptomatic. If left untreated or if antibiotic treatment is delayed, Lyme arthritis can become persistent and lead to long-term joint damage. Early recognition and prompt antibiotic therapy are essential for successful treatment, helping to resolve joint swelling and restore function. Addressing Lyme arthritis early not only alleviates pain but also prevents the progression to chronic joint issues, supporting better outcomes for patients.
Diagnosis and Testing
Accurate diagnosis of Lyme disease and Lyme arthritis involves a combination of clinical assessment, laboratory testing, and a thorough review of the patient’s medical history. The Centers for Disease Control and Prevention (CDC) recommend a two-step testing process: an initial enzyme-linked immunosorbent assay (ELISA) to screen for antibodies against Borrelia burgdorferi, followed by a confirmatory Western blot test if the first result is positive or equivocal. These blood tests help detect the immune response to the Lyme disease causing bacteria, although results may be negative in the early stages before antibodies develop.
For patients presenting with joint swelling, especially in large joints, synovial fluid analysis and joint aspiration can be valuable tools. These procedures help distinguish Lyme arthritis from other conditions such as septic arthritis or reactive arthritis, ensuring that the correct treatment is provided. A comprehensive clinical assessment, including a detailed history of tick exposure and physical examination, is crucial for guiding diagnosis and determining the most effective treatment plan.
Traditional Treatment for Lyme Disease
The standard medical treatment for Lyme disease includes:
- Antibiotics: Oral treatment with antibiotics such as doxycycline or amoxicillin is the first-line approach for early Lyme disease. Intravenous antibiotics may be used for more severe or late-stage cases.
- Pain relievers: Over-the-counter medications can help manage joint pain and inflammation.
- Supportive care: Rest and hydration are important during recovery.
Antibiotic management should ideally follow established clinical practice guidelines, such as those from the Infectious Diseases Society of America, to ensure appropriate and effective care. Other antibiotics may be considered for patients who do not respond to first-line therapy or who have specific complications.
The treatment of Lyme disease, including Lyme arthritis, is discussed in detail in journals such as Infect Dis and Infect Dis Clin North Am.
💊 Antibiotics
- Doxycycline, amoxicillin, or cefuroxime in early Lyme disease
- IV antibiotics (e.g., ceftriaxone) in cases of neurologic Lyme or cardiac complications
- Typical duration: 2 to 4 weeks, depending on clinical guidelines
While most patients with Lyme improve with these antibiotic treatments, which are considered effective treatments for the majority, some patients with Lyme may require additional or alternative treatments to address persistent symptoms. A subset experiences ongoing symptoms long after antibiotics end.
When Pain Persists: What Causes Ongoing Lyme Disease Symptoms?
Some patients develop chronic Lyme disease symptoms even after the infection is gone. These may include:
- Persistent joint inflammation
- Autoimmune responses
- Central sensitization (nervous system overactivation)
- Dysregulated immune function
- Immunologic factors and immune system dysregulation can contribute to ongoing symptoms.
Persistent arthritis is a common long-term complication for some patients, requiring ongoing management.
This is where traditional medicine often falls short—and where integrative and regenerative care becomes essential.
Effective Strategies for Lyme Disease Pain Relief
If you’re dealing with long-term pain, fatigue, or joint dysfunction, a variety of treatment approaches are available for managing Lyme disease pain, tailored to individual patient needs. Here are proven, supportive treatment options offered at PointHealth Clinic:
✅ 1. IV Therapy for Immune Support & Detoxification
High-dose IV vitamin therapy can reduce inflammation, boost immune response, and replenish nutrient deficiencies caused by long-term illness.
Popular IVs include:
- Vitamin C – Anti-inflammatory and immune-modulating
- Glutathione – Cellular detoxification and neuroprotection
- NAD+ – Mitochondrial support for energy and brain function
✅ 2. Stem Cell Therapy for Joint and Nerve Pain
Lyme-related joint pain and neurologic damage may benefit from targeted regenerative therapies, such as:
- Stem cell injections to reduce joint inflammation and promote repair
- Exosome therapy for systemic inflammation and immune regulation
- Nerve-targeted injections to address burning, tingling, or numbness
These therapies help repair damaged tissue, rather than just masking the symptoms with medications.
✅ 3. Non-Steroidal Anti-Inflammatory Approaches (Without Long-Term Drugs)
While NSAIDs (ibuprofen, naproxen) can offer temporary relief, long-term use isn’t ideal.
At PointHealth, we use:
- Ozone therapy for natural anti-inflammatory effects
- UV blood irradiation to reduce microbial load and inflammation
- Peptide therapy to modulate immune response and repair damaged tissues
✅ 4. Pain Mapping & Injection Therapy
We provide precise pain mapping to target inflamed tissues and nerves. Our non-opioid injections offer immediate relief and support healing.
Great for:
- Lyme arthritis in knees or large joints
- Neuropathy symptoms
- Spinal discomfort related to nerve inflammation
✅ 5. Lifestyle and Complementary Support
Managing Lyme disease pain also involves holistic care:
- Sleep optimization
- Anti-inflammatory diets
- Stress reduction (breathwork, mindfulness)
- Physical therapy and movement plans
- Addressing co-infections or mold exposure
Our integrative team customizes your program based on symptom severity, lab markers, and clinical progression.
Preventing Long-Term Damage
Preventing long-term complications from Lyme disease starts with early and effective antibiotic treatment. Timely intervention with oral or intravenous antibiotics is the cornerstone of treatment for Lyme disease and is especially important in preventing the development of Lyme arthritis and other late-stage manifestations. In addition to antibiotic therapy, patients should take steps to avoid tick bites, such as using insect repellents and performing regular tick checks after outdoor activities.
For those already diagnosed, ongoing monitoring for persistent symptoms—such as joint pain, swelling, or signs of neurologic Lyme disease—is essential. Nonsteroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents can help manage joint pain and inflammation, supporting recovery during and after antibiotic therapy. Some patients may experience persistent joint inflammation or other symptoms even after treatment, requiring continued care and follow-up to prevent long-term damage. By working closely with healthcare providers and following evidence-based treatment for Lyme disease, patients can reduce the risk of chronic complications and achieve the best possible outcomes.
When Should You Seek Advanced Lyme Support?
If any of the following apply, it’s time to explore advanced options:
- You’ve completed antibiotic therapy but still experience pain
- You have swollen joints, brain fog, fatigue, or burning nerve pain
- Traditional medications have provided limited or short-term relief
- You’re looking for a non-opioid, non-toxic path to recovery
If symptoms persist despite treatment, further diagnostic testing may be necessary to rule out ongoing infection or complications. Pregnant women with suspected or confirmed Lyme disease should seek specialized medical care to ensure safe and effective treatment.
Why Choose PointHealth Clinic?
At PointHealth, we go beyond symptom suppression. We focus on:
- 🌿 Restoring immune function
- 🔬 Reducing systemic inflammation
- 🧠 Repairing neurological and joint damage
- 💧 Rebuilding energy and vitality
Our team has helped countless Lyme disease patients reduce their pain, regain mobility, and reclaim their lives.
Start Your Healing Today
📍 Clinics located in Encino, Malibu, Redondo Beach, and throughout Los Angeles
📞 Call (855) 263-1487
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🌐 Visit www.pointhealthclinic.com
✅ Schedule a consultation today and discover how advanced therapies can help you recover from chronic Lyme disease pain—physically, mentally, and immunologically.
